沈亚欧，女，1979年10月出生，博士，研究员，博士生导师，四川省学术和技术带头人后备人选。2014年4月至2015年4月在美国爱荷华州立大学进行访问学习。现主要研究方向为玉米重要性状基因功能及转基因育种，先后完成了玉米幼胚培养相关性状QTL定位、玉米细胞质雄性不育miRNA、玉米纹枯病胁迫miRNA功能、玉米幼胚脱分化分子机理、玉米耐重金属胁迫机理、玉米产量基因克隆及高产转基因玉米新品种培育等领域研究。已创制产量性状明显改善的转基因玉米自交系3个，主研育成玉米新品种汉单999一个，鉴定国家级和省级成果各1项。先后主持国家自然科学基金项目3项、国家973计划项目子课题1项、国家转基因重大专项子课题1项、四川省杰出青年基金1项、四川省教育厅重点项目1项、国家自然科学基金重大研究计划子项目1项。已获授权发明专利2项、实用新型专利8项。近三年来在《Trends in Biotechnology》、 《PNAS》、 《Plos one》、 《Funct Integr Genomemics》、 《Physiologia Plantarum》等国际主流期刊上发表论文数篇。
研究领域
玉米重要性状基因功能、玉米基因工程
科研情况
1. “玉米抗纹枯病相关miRNA的克隆及功能分析”，国家自然科学基金青年基金，2010.01-2012.12，负责人；
2.“调控玉米胚性愈伤组织发生的miRNA功能鉴定”，四川省教育厅重点项目，2011.09-2013.09，负责人；
3. “玉米幼胚胚性愈伤组织诱导过程中重要miRNA及靶转录因子的功能研究”，国家自然科学基金面上项目，2013.01-2016.12，负责人；
4. 基于IBM群体的玉米产量性状全基因组遗传解析，国家973计划项目子课题，2014.01-2018.12，负责人；
5.“玉米耐密、耐阴湿、大粒等相关基因的遗传转化和材料筛选”，国家重大转基因专项子课题，2013.01-2017.12，负责人；
6.“玉米幼胚胚性愈伤组织诱导能力全基因组遗传解析”国家自然科学基金面上项目，2015.01-2018.12，负责人；
7. 玉米愈伤组织再生能力全基因组遗传解析，四川省杰出青年基金，2016.01-2018.12，负责人；
8. 玉米胚乳蛋白质组平衡和优质蛋白玉米胚乳修饰机理研究，国家自然科学基金重大研究计划子项目，2014,01-2016,12，负责人
近三年科研经费300万元，年均100万元。
曾获荣誉
1. 沈亚欧，潘光堂，江舟，杨珊，林海建，彭焕伟，张志明，罗旭，马浪浪，李婉蓉，张兵.“以单倍体玉米茎尖为受体的转基因育种方法”发明专利，专利号：ZL201210448146.3
2. 张志明，沈亚欧，畅乃迪，潘光堂，林海健，赵茂俊，马永毅，丁海萍.“农杆菌介导的高效玉米遗传转化方法”，发明专利，专利号：ZL200810147825.0
3. 沈亚欧，彭焕伟，杨珊，缪林，潘光堂，张志明，林海建.“一种数显示温涂布棒”，实用新型专利，专利号：ZL201220505737.5
4. 沈亚欧, 杨珊，林海建，刘红军，潘光堂，缪林,“一种新型的转基因专用茎尖分生组织侵染皿”，实用新型专利，专利号：ZL201320295177.X
5. 沈亚欧，刘敏，吴光秀，周伦理，潘光堂，林海建. “多用途植物组织培养刀镊”，实用新型专利，专利号：ZL201420134162.X
6. 沈亚欧，葛飞，吴花拉，彭焕伟，赵雄伟.“定量微量移液器吸头”，实用新型专利，专利号：ZL201420047742.5
7. 沈亚欧, 刘敏, 张晓玲, 彭焕伟, 高世斌, 林海建. “多用途植物幼胚挑胚组件”, 实用新型专利，专利号：ZL201520224947.0
8. 沈亚欧, 刘敏, 韩善冬, 彭焕伟, 林海建. “愈伤组织洗菌瓶”，实用新型专利，专利号：ZL201420711144.3
9. 沈亚欧 刘敏 李婉蓉 杨勇 彭焕伟 林海建.“水槽式光照培养架”, 实用新型专利，专利号：ZL 201420296109.X
10. 沈亚欧，张严玲，吴花拉，彭焕伟，葛飞. “幼苗水培箱及具有该水培箱的生化培养箱”,实用新型专利，专利号：ZL201520425766.4
发表论文
1. Fei Ge, Hongmei Hu, Xing Huang, Yanling Zhang, Yanli Wang, Zhaoling Li, Chaoying Zou, Huanwei Peng, Lujiang Li, Shibin Gao, Guangtang Pan, Yaou Shen*. Metabolomic and proteomic analysis of maize embryonic callus induced from immature embryo. Scientific Reports (IF=5.28), 2017, 7: 1004
2. Hongjun Liu, Langlang Ma, Xuerong Yang, Lin Zhang, Xing Zeng, Shupeng Xie, Huanwei Peng, Shibin Gao, Haijian Lin, Guangtang Pan, Yongrui Wu, Yaou Shen*. Integrative analysis of DNAs during maize embryo dedifferentiation. BMC Plant Biology, 2017, 17:105
3. Yanling Zhang, Fei Ge, Fengxia Hou, Wenting Sun, Qi Zheng, Xiaoxiang Zhang, Langlang Ma, Jun Fu, Xiujing He, Huanwei Peng, Guangtang Pan, Yaou Shen*. Transcription factors responding to Pb stess in maize. Genes, 2017, 8, 231
4. Fei Ge, Xing Huang, Hongmei Hu, Yanling Zhang, Yanli Wang, Zhaoling Li, Chaoying Zou, Huanwei Peng, Lujiang Li, Shibin Gao, Guangtang Pan, Yaou Shen*. Endogenous small interfering RNAs associated with maize embryonic callus formation. PLoS One, 2017, e0180567
5. Fei Ge, Xu Luo, Xing Huang, Yanling Zhang, Xiujing He, Min Liu, Haijian Lin, Huanwei Peng, Lujiang Li, Zhiming Zhang, Guangtang Pan, Yaou Shen*. Genome-wide analysis oftranscription factors involved in maize embryonic callus formation. Physiologia Plantarum, 2016, doi: 10.1111/ppl.12470
6. Yaou Shen*, Guangtang Pan, Thomas Lubberstedt*. Haploid strategies for functional validation of plant genes. Trends in Biotechnology (IF=11.96), 2015, 33(10):611-620.
7. Cheng Qin, Changshui Yu, Yaou Shen（Co-first author）, Xiaodong Fang, Lang Chen, Jiumeng Min, Ye Yin, Jiping Yu, Kailin Hu, and Zhiming Zhang* et al. Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization. PNAS (IF=9.74),2014,111(14):5135-5140
8. Yaou Shen, Zhou Jiang, Xiadong Yao, Zhiming Zhang, Haijian Lin, Maojun Zhao, Hailan Liu, Huanwei Peng, Shujun Li, Guangtang Pan*. Genome expression profile analysis of the immature maize embryo during dedifferentiation, Plos one (IF=4.41), 2012, DOI:10.1371/journal.pone.0032237
9. Yaou Shen, Zhiming Zhang, Haijian Lin, Hailan Liu, Jie Chen, Hua Peng, Moju Cao, Tingzhao Rong, Guangtang Pan*. Cytoplasmic male sterility-regulated novel microRNAs from maize. Funct Integr Genomics (IF=3.82), 2011, 11(1):179-191
10. Yaou Shen, Yongzhong Zhang, Jie Chen, Haijian Lin, Maojun Zhao, Huanwei Peng, Li Liu, Guangsheng Yuan, Zhiming Zhang, Suzhi Zhang, Guangtang Pan*. Genome expression profile analysis reveals important transcripts in maize roots responding to the stress of heavy metal Pb. Phyisologia Plantarum (IF=3.11), 2013,147（3）：270-28211. Yaou Shen, Zhou Jiang, Sifen Lu, Haijian Lin, Shibin Gao, Huanwei Peng, Guangsheng Yuan, Li Liu, Zhiming Zhan, Maojun Zhao, Tingzhao Rong, Guangtang Pan*. Combined small RNA and degradome sequencing reveals microRNA regulation during immature maize embryo dedifferentiation. BBRC (IF=2.46), 2013，441：425-430
12. Yaou Shen，Shujun Li，Zhou Jiang, Langlang Ma，Haijian Lin, Huanwei Peng，Li Liu，Guangsheng Yuan，Maojun Zhao，Shibin Gao，Zhiming Zhang，Guangtang Pan*. Overexpression of an Incw2 gene in endosperm improved yield-related traits in maize. Maydica (IF=0.4), 2012, 57: 147-153
13. Yaou Shen, Hongning Wang, Guangtang Pan*. Improving Inorganic Phosphorus Content in Maize Seeds by Introduction of Phytase Gene. Biotechnology, 2008, 7(2): 323-327
14. Yaou Shen, Yongzhong Zhang, Haijian Lin, Shibin Gao, Guangtang Pan*. Effect of low phosphorus stress on endogenous hormone levels of different maize genotypes in seedling stage. Journal of Biological Sciences, 2012,12(5):308-314
15. 沈亚欧，李淑君，林海建，张志明，江舟，何晶，潘光堂*.通过转基因手段改善作物产量性状. 农业生物技术学报，2011,19（4）：753-726
16. 沈亚欧，林海建，张志明，高世斌，潘光堂*. 植物逆境miRNA研究进展. 遗传，2009，31(3): 227-235
17. 沈亚欧，彭焕伟，潘光堂*. 转基因植物表达植酸酶的研究进展. 中国生物工程杂志，2005，25（1）：25-32
18. Fei Ge, Maojun Zhao, Haijian Lin, Guangtang Pan and Yaou Shen*. Study on the Growth Inhibition Ratio of Rhizoctonia Solani Controlled by Nano-Al2O3/TiO2, Journal of Food Agriculture & Environment 2014(12)2: 1168-1171.(SCI, IF=0.5)
19. Junqiu Luo, Huanwei Peng, Yaou Shen*. Interorgan metabolism of nitrogen in nonruminants. Journal of Food, Agriculture & Environment, 2012, 10 (2): 598-602. (SCI, IF=0.5)
20. 马浪浪，江舟，黄小波，沈亚欧*，潘光堂. 植物DNA甲基化调控研究进展. 中国生物工程杂志，2013，33（9）：101-110
21. 吴花拉，张严玲，罗旭，葛飞，潘光堂，沈亚欧* . 位点特异性重组系统及其在植物转基因研究中的应用. 中国生物工程杂志，2014,34（11）：107-118
22. 杨珊, 王静, 李清超, 刘丽, 张志明, 潘光堂, 沈亚欧*. 玉米自交系K10白色叶鞘遗传机理研究. 植物遗传资源学报，2014， 15（6）： 1167-1172
23. Hailan Liu, Yueai Lin, Guobo Chen, Yaou Shen, Jian Liu and Suzhi Zhang*. Genome-scale identification of resistance gene analogs and the development of their intron length polymorphism markers in maize. Molecular breeding, 2011, DOI: 10.1007/s11032-011-9560-3.(IF=2.0)
24. Fei Zheng, Guiqin Mu, Zhiming Zhang, Yaou Shen, Maojun Zhao, Guangtang Pan*. Nitrogen-doped hollow macroprous carbon spheres with high electrocatalytic activity for oxygen reduction. Materials Letters, 2011, doi:10.1016/j.matlet.2011.11.035 Key: citeulike:10047427.(IF=2.2)
25. Meng Xu, Yunsong Zhang, Zhiming Zhang, Yaou Shen, Maojun Zhao, Guangtang Pan*. Study on the adsorption of Ca2+. Cd2+ and Pb2+ by magnetic Fe3O4 yeast treated withEDTA dianhydride. Chemical Engineering Journal, 2011, 168:737-745. (IF=3.01).
26. Hongjun Liu, Xuerong Yang，et al., Yaou Shen, Haijian Lin, Thomas Lübberstedt, Zhiming Zhang, Guangtang Pan* .Genome-wide comparative analysis of digital gene expression tag profiles during maize ear development. Genomics, 2015, 106(1): 52-60
27. Fuqiang Yin, Cheng Qin, Jian Gao, Ming Liu, Xirong Luo, Wenyou Zhang, Hongjun Liu, Xinhui Liao, Yaou Shen, Likai Mao, Zhiming Zhang, Haijian Lin, Thomas Lübberstedt, and Guangtang Pan*. Genome-Wide Identification and Analysis of Drought-Responsive Genes and MicroRNAs in Tobacco. Int. J. Mol. Sci. 2015, 16, 5714-5740
28. Jian Gao, Yongzhong Zhang, Chaolong Lu, Hua Peng, Mao Luo, Gaoke Li, Yaou Shen, Haiping Ding, Zhiming Zhang, Guangtang Pan*, Haijian Lin*. The development dynamics of the maize root transcriptome responsive to heavy metal Pb pollution. Biochemical and Biophysical Research Communications, 2015, 458(2): 287-293
29. Haiping Ding, Jian Gao, Cheng Qin, Haixia Ma, Hong Huang, Pan Song, Xirong Luo, Haijian Lin, Yaou Shen, Guangtang Pan* and Zhiming Zhang*. The Dynamics of DNA Methylation in Maize Roots under Pb Stress. Int. J. Mol. Sci. 2014, 15, 23537-23554
30. Hongjun Liu, Cheng Qin, Zhe Chen, Tao Zuo, Xuerong Yang, Huangkai Zhou, Meng Xu, Shiliang Cao, Yaou Shen, Haijian Lin, Xiujing He, Yinchao Zhang, Lujiang Li, Haiping Ding, Thomas Lübberstedt, Zhiming Zhang*, Guangtang Pan*. Identification of miRNAs and their target genes in developing maize ears by combined small RNA and degradome sequencing. BMC Genomics, 2014, 15:25
31. Jian Gao, Zhe Chen, Mao Luo, Hua Peng, Haijian Lin, Cheng Qin, Guangsheng Yuan, Yaou Shen, Haiping Ding, Maojun Zhao, Guangtang Pan*, Zhiming Zhang*. Genome expression profile analysis of the maize sheath in response to inoculation to R. solani. Mol Biol Rep, 2014, 41:2471–2483
32. Haiping Ding, Cheng Qin, Xirong Luo, Lujiang Li, Zhe Chen, Hongjun Liu, Jian Gao, Haijian Lin, Yaou Shen, Maojun Zhao, Thomas Lübberstedt, Zhiming Zhang*, and Guangtang Pan*. Heterosis in early maize ear inflorescence development: A genome-wide transcription analysis for two maize inbred lines and their hybrid. Int J Mol Sci, 2014, 15, 13892-13915
33. Su Shunzong, Wu Ling, Liu Dan, Lu Yanli, Lin Haijian, Zhang Shuzhi, Shen Yaou, Liu Hailan, Zhang Zhiming, Rong Tingzhao, Zhang Xiao, Tian Yuehui, Nie Zhi, Gao Shibin*. Genome-wide expression profile of maize root response to phosphorus deficiency revealed by deep sequencing. Journal of Integrative Agriculture, 2014, 13(6), 1216-1229
34. Haiping Ding, Jian Gao, Mao Luo, Hua Peng, Haijian Lin, Guangsheng Yuan, Yaou Shen, Maojun Zhao, Guangtang Pan*, Zhiming Zhang*. Identification and functional analysis of miRNAs in developing kernels of a viviparous mutant in maize. The crop journal, 2013, 1(2): 115-126
35. Guangsheng Yuan, Zhiming Zhang, Kui Xiang, Yaou Shen, Juan Du, Haijian Lin & Li Liu, Maojun Zhao, Guangtang Pan*. Different Gene Expressions of Resistant and Susceptible Maize Inbreds in Response to Fusarium verticillioides Infection. Plant Mol Biol Rep, 2013, 31: 925–935
36. Guang-Sheng Yuan, Kui Xiang, Zhi-Ming Zhang, Ya-Ou Shen, Juan Du, Hai-Jian Lin, Li Liu and Guang-Tang Pan*. Analysis on the relationship between Fusarium verticillioides infection-induced genes and ear rot resistance in maize. Journal: Food, Agriculture and Environment, 2013, 11(2): 363-366
37. Zhiming Zhang, Jin Feng, Cui Wang, Jun Luo, Haijian Lin, Kui Xiang, Li Liu, Maojun Zhao, Yunsong Zhang, Haiping Ding, Shufeng Zhou, Yaou Shen and Guangtang Pan*. Difference between Pb and Cd Accumulation in 19 Elite Maize Inbred Lines and Application Prospects. Journal of Biomedicine and Biotechnology, 2012, 2012: 271485
38. Zhiming Zhang, Haijian Lin, Yaou Shen, Jian Gao, Kui Xiang, Li Liu, Haiping Ding, Guangsheng Yuan, Hai Lan, Shufeng Zhou, Maojun Zhao, Shibin Gao, Tingzhao Rong, Guangtang Pan*. Cloning and characterization of miRNAs from maize seedling roots under low phosphorus stress. Molecular biology report, 2012, 39: 8137-8146
39. Yuan Guangsheng, Zhang Zhiming†, Xiang Kui, Zhao Maojun, Shen Yaou, Pan Guangtang*. Large-scale identification of differentially expressed genes in maize inbreds susceptible and resistant to Fusarium ear rot. Plant omics journal, 2012, 9(5): 471-475
40. Hongjun Liu ,Huangkai Zhou ,Yongsheng Wu ,Xiao Li, Jing Zhao, Tao Zuo, Xuan Zhang, Yongzhong Zhang, Sisi Liu, Yaou Shen, Haijian Lin, Zhiming Zhang, Kaijian Huang,Thomas Lübberstedt,Guangtang Pan*. The Impact of Genetic Relationship and Linkage Disequilibrium on Genomic Selection. PLoS One, 10(7): e0132379
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